Publications

2025. Vascular protection by young circulating extracellular vesicles ameliorates aging-related pulmonary fibrosis. American Journal of Physiology - Cell Physiology. Fiorenza Giani', Benjamin B. Roos, Patrick A. Link, Bharath Somasundram, Sara Dresler, Enrico Sciacca, Carlo Vancheri, Naureen Javeed, Giovanni Ligresti, Daniel J. Tschumperlin, Nunzia Caporarello

2024. Lung injury-induced activated endothelial cell states persist in aging-associated progressive fibrosis. Nature Communications. Ahmed A. Raslan, Tho X Pham, Jisu Lee, Konstantinos Kontodimas, Andrew Tilston-Lunel, Jillian Schmottlach, Jeongmin Hong, Taha Dinc, Andreea M. Bujor, Nunzia Caporarello, Aude Thiriot, Ulrich H. von Andrian,Steven K. Huang, Roberto F. Nicosia, Maria Trojanowska, Xaralabos Varelas, Giovanni Ligresti

2023. Vascular contribution to lung repair and fibrosis. American Journal of Respiratory Cell and Molecular Biology. Nunzia Caporarello and Giovanni Ligresti

2022. The matricellular protein CCN3 promotes lung endothelial homeostasis and function. American Journal of Physiology - Lung Cellular  and Molecular Physiology. Kalpana R Betageri, Patrick A Link, Andrew J Haak, Giovanni Ligresti, Daniel J Tschumperlin, Nunzia Caporarello

2022. Dysfunctional ERG signaling drives pulmonary vascular aging and persistent fibrosis. Nature Communications. Caporarello N, Lee J, Pham TX, Guan J, Jones DL, Link PA, Meridew JA, Marden G, Yamashita T, Huang SK, Nicosia RF, Tschumperlin DJ, Trojanowska M, Ligresti G.

2020. Vascular dysfunction in aged mice contributes to persistent lung fibrosis. Aging Cell. Caporarello N, Meridew JA, Aravamudhan A, Jones DL, Austin SA, Pham TX, Haak AJ, Moo Choi K, Tan Q, Haresi A, Huang SK, Katusic ZS, Tschumperlin DJ, Ligresti G.

2019. PGC1alpha repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state. Thorax. Caporarello N, Meridew JA, Jones DL, Tan Q, Haak AJ, Choi KM, Manlove LJ, Prakash YS, Tschumperlin DJ, Ligresti G.